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YAP induces high-grade serous carcinoma in fallopian tube secretory epithelial cells.
Hua, G; Lv, X; He, C; Remmenga, S W; Rodabough, K J; Dong, J; Yang, L; Lele, S M; Yang, P; Zhou, J; Karst, A; Drapkin, R I; Davis, J S; Wang, C.
Afiliação
  • Hua G; Olson Center for Women's Health, Department of Obstetrics/Gynecology, University of Nebraska Medical Center, Omaha, NE, USA.
  • Lv X; The Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of the Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, China.
  • He C; Olson Center for Women's Health, Department of Obstetrics/Gynecology, University of Nebraska Medical Center, Omaha, NE, USA.
  • Remmenga SW; Olson Center for Women's Health, Department of Obstetrics/Gynecology, University of Nebraska Medical Center, Omaha, NE, USA.
  • Rodabough KJ; The Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of the Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, China.
  • Dong J; Olson Center for Women's Health, Department of Obstetrics/Gynecology, University of Nebraska Medical Center, Omaha, NE, USA.
  • Yang L; Olson Center for Women's Health, Department of Obstetrics/Gynecology, University of Nebraska Medical Center, Omaha, NE, USA.
  • Lele SM; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.
  • Yang P; The Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of the Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, China.
  • Zhou J; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.
  • Karst A; Department of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Drapkin RI; Department of Obstetrics and Gynecology, Urumuqi General Hospital of Lanzhou Military Region, Urumuqi, China.
  • Davis JS; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Wang C; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Oncogene ; 35(17): 2247-65, 2016 04 28.
Article em En | MEDLINE | ID: mdl-26364602
ABSTRACT
Accumulating evidence indicates that ovarian high-grade serous carcinoma (HGSC) originates from fallopian tube secretory epithelial cells (FTSECs). However, the molecular mechanisms underlying the initiation and progression of HGSC derived from FTSECs remains unclear. In this study, we found that the Hippo/Yes-associated protein (YAP) signaling pathway has a critical role in the initiation and progression of fallopian tube and ovarian HGSC. Importantly, YAP was overexpressed in inflammatory and cancerous fallopian tube tissues. Further, overexpression of wild-type YAP, or constitutively active YAP in immortalized FTSECs, induced cell proliferation, migration, colony formation and tumorigenesis. Moreover, the Hippo/YAP and the fibroblast growth factor (FGF) signaling pathways formed an autocrine/paracrine-positive feedback loop to drive the progression of the FTSEC-derived HGSC. Evidence in this study strongly suggests that combined therapy with inhibitors of YAP (such as verteporfin) and FGF receptors (such as BGJ398) can provide a novel therapeutic strategy to treat fallopian tube and ovarian HGSC.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Fosfoproteínas / Cistadenocarcinoma Seroso / Proteínas Adaptadoras de Transdução de Sinal / Neoplasias das Tubas Uterinas / Carcinogênese Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Fosfoproteínas / Cistadenocarcinoma Seroso / Proteínas Adaptadoras de Transdução de Sinal / Neoplasias das Tubas Uterinas / Carcinogênese Idioma: En Ano de publicação: 2016 Tipo de documento: Article