Your browser doesn't support javascript.
loading
Population genetic differentiation of height and body mass index across Europe.
Robinson, Matthew R; Hemani, Gibran; Medina-Gomez, Carolina; Mezzavilla, Massimo; Esko, Tonu; Shakhbazov, Konstantin; Powell, Joseph E; Vinkhuyzen, Anna; Berndt, Sonja I; Gustafsson, Stefan; Justice, Anne E; Kahali, Bratati; Locke, Adam E; Pers, Tune H; Vedantam, Sailaja; Wood, Andrew R; van Rheenen, Wouter; Andreassen, Ole A; Gasparini, Paolo; Metspalu, Andres; Berg, Leonard H van den; Veldink, Jan H; Rivadeneira, Fernando; Werge, Thomas M; Abecasis, Goncalo R; Boomsma, Dorret I; Chasman, Daniel I; de Geus, Eco J C; Frayling, Timothy M; Hirschhorn, Joel N; Hottenga, Jouke Jan; Ingelsson, Erik; Loos, Ruth J F; Magnusson, Patrik K E; Martin, Nicholas G; Montgomery, Grant W; North, Kari E; Pedersen, Nancy L; Spector, Timothy D; Speliotes, Elizabeth K; Goddard, Michael E; Yang, Jian; Visscher, Peter M.
Afiliação
  • Robinson MR; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
  • Hemani G; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
  • Medina-Gomez C; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Mezzavilla M; Institute for Maternal and Child Health, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) 'Burlo Garofolo', Trieste, Italy.
  • Esko T; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.
  • Shakhbazov K; Estonian Genome Center, University of Tartu, Tartu, Estonia.
  • Powell JE; Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts, USA.
  • Vinkhuyzen A; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Berndt SI; Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.
  • Gustafsson S; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
  • Justice AE; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
  • Kahali B; University of Queensland Diamantina Institute, University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia.
  • Locke AE; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
  • Pers TH; Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA.
  • Vedantam S; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
  • Wood AR; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  • van Rheenen W; Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
  • Andreassen OA; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA.
  • Gasparini P; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.
  • Metspalu A; Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts, USA.
  • Berg LH; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Veldink JH; Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.
  • Rivadeneira F; Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark.
  • Werge TM; Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts, USA.
  • Abecasis GR; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Boomsma DI; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.
  • Chasman DI; Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands.
  • de Geus EJ; Norwegian Centre for Mental Disorders Research (NORMENT), KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Frayling TM; Institute for Maternal and Child Health, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) 'Burlo Garofolo', Trieste, Italy.
  • Hirschhorn JN; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.
  • Hottenga JJ; Estonian Genome Center, University of Tartu, Tartu, Estonia.
  • Ingelsson E; Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands.
  • Loos RJ; Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands.
  • Magnusson PK; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Martin NG; Institute of Biological Psychiatry, MHC Sct. Hans, Mental Health Devices Copenhagen, Roskilde, Denmark.
  • Montgomery GW; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • North KE; Lundbeck Foundation Initiative for Integrative Psychiatric Research, (iPSYCH), Aarhus, Denmark.
  • Pedersen NL; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.
  • Spector TD; Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands.
  • Speliotes EK; EMGO+ Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands.
  • Goddard ME; Department of Biological Psychology, VU University Amsterdam, Amsterdam, the Netherlands.
  • Yang J; Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.
  • Visscher PM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Nat Genet ; 47(11): 1357-62, 2015 Nov.
Article em En | MEDLINE | ID: mdl-26366552
ABSTRACT
Across-nation differences in the mean values for complex traits are common, but the reasons for these differences are unknown. Here we find that many independent loci contribute to population genetic differences in height and body mass index (BMI) in 9,416 individuals across 14 European countries. Using discovery data on over 250,000 individuals and unbiased effect size estimates from 17,500 sibling pairs, we estimate that 24% (95% credible interval (CI) = 9%, 41%) and 8% (95% CI = 4%, 16%) of the captured additive genetic variance for height and BMI, respectively, reflect population genetic differences. Population genetic divergence differed significantly from that in a null model (height, P < 3.94 × 10(-8); BMI, P < 5.95 × 10(-4)), and we find an among-population genetic correlation for tall and slender individuals (r = -0.80, 95% CI = -0.95, -0.60), consistent with correlated selection for both phenotypes. Observed differences in height among populations reflected the predicted genetic means (r = 0.51; P < 0.001), but environmental differences across Europe masked genetic differentiation for BMI (P < 0.58).
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Variação Genética / Estatura / Índice de Massa Corporal / Genética Populacional Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Variação Genética / Estatura / Índice de Massa Corporal / Genética Populacional Idioma: En Ano de publicação: 2015 Tipo de documento: Article