Increased white matter neuron density in a rat model of maternal immune activation - Implications for schizophrenia.
Prog Neuropsychopharmacol Biol Psychiatry
; 65: 118-26, 2016 Feb 04.
Article
em En
| MEDLINE
| ID: mdl-26385575
ABSTRACT
Interstitial neurons are located among white matter tracts of the human and rodent brain. Post-mortem studies have identified increased interstitial white matter neuron (IWMN) density in the fibre tracts below the cortex in people with schizophrenia. The current study assesses IWMN pathology in a model of maternal immune activation (MIA); a risk factor for schizophrenia. Experimental MIA was produced by an injection of polyinosinicpolycytidylic acid (PolyIC) into pregnant rats on gestational day (GD) 10 or GD19. A separate control group received saline injections. The density of neuronal nuclear antigen (NeuN(+)) and somatostatin (SST(+)) IWMNs was determined in the white matter of the corpus callosum in two rostrocaudally adjacent areas in the 12week old offspring of GD10 (n=10) or GD19 polyIC dams (n=18) compared to controls (n=20). NeuN(+) IWMN density trended to be higher in offspring from dams exposed to polyIC at GD19, but not GD10. A subpopulation of these NeuN(+) IWMNs was shown to express SST. PolyIC treatment of dams induced a significant increase in the density of SST(+) IWMNs in the offspring when delivered at both gestational stages with more regionally widespread effects observed at GD19. A positive correlation was observed between NeuN(+) and SST(+) IWMN density in animals exposed to polyIC at GD19, but not controls. This is the first study to show that MIA increases IWMN density in adult offspring in a similar manner to that seen in the brain in schizophrenia. This suggests the MIA model will be useful in future studies aimed at probing the relationship between IWMNs and schizophrenia.
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MEDLINE
Assunto principal:
Efeitos Tardios da Exposição Pré-Natal
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Esquizofrenia
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Encéfalo
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Substância Branca
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Doenças do Sistema Imunitário
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Neurônios
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article