Physiologically-Based Pharmacokinetic Modeling of Macitentan: Prediction of Drug-Drug Interactions.

de Kanter, Ruben; Sidharta, Patricia N; Delahaye, Stéphane; Gnerre, Carmela; Segrestaa, Jerome; Buchmann, Stephan; Kohl, Christopher; Treiber, Alexander

de Kanter, Ruben; Sidharta, Patricia N; Delahaye, Stéphane; Gnerre, Carmela; Segrestaa, Jerome; Buchmann, Stephan; Kohl, Christopher; Treiber, Alexander.

Afiliação

de Kanter R; Preclinical Pharmacokinetics and Metabolism, Actelion Pharmaceuticals Ltd, Gewerbestrasse 16, 4123, Allschwil, Switzerland. ruben.de-kanter@actelion.com.
Sidharta PN; Clinical Pharmacology, Actelion Pharmaceuticals Ltd, Gewerbestrasse 16, 4123, Allschwil, Switzerland.
Delahaye S; Preclinical Pharmacokinetics and Metabolism, Actelion Pharmaceuticals Ltd, Gewerbestrasse 16, 4123, Allschwil, Switzerland.
Gnerre C; Preclinical Pharmacokinetics and Metabolism, Actelion Pharmaceuticals Ltd, Gewerbestrasse 16, 4123, Allschwil, Switzerland.
Segrestaa J; Preclinical Pharmacokinetics and Metabolism, Actelion Pharmaceuticals Ltd, Gewerbestrasse 16, 4123, Allschwil, Switzerland.
Buchmann S; Preformulation and Preclinical Galenics, Actelion Pharmaceuticals Ltd, Gewerbestrasse 16, 4123, Allschwil, Switzerland.
Kohl C; Preclinical Pharmacokinetics and Metabolism, Actelion Pharmaceuticals Ltd, Gewerbestrasse 16, 4123, Allschwil, Switzerland.
Treiber A; Preclinical Pharmacokinetics and Metabolism, Actelion Pharmaceuticals Ltd, Gewerbestrasse 16, 4123, Allschwil, Switzerland.

Clin Pharmacokinet ; 55(3): 369-80, 2016 Mar.

Article em En | MEDLINE | ID: mdl-26385839

Assuntos

Antagonistas do Receptor de Endotelina A/farmacocinética; Antagonistas do Receptor de Endotelina B/farmacocinética; Modelos Biológicos; Pirimidinas/farmacocinética; Sulfonamidas/farmacocinética; Adulto; Ciclosporina/farmacologia; Citocromo P-450 CYP3A/metabolismo; Inibidores do Citocromo P-450 CYP3A/farmacologia; Interações Medicamentosas; Humanos; Cetoconazol/farmacologia; Masculino; Pirimidinas/sangue; Rifampina/farmacologia; Citrato de Sildenafila/farmacologia; Sulfonamidas/sangue; Varfarina/farmacologia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Sulfonamidas / Antagonistas do Receptor de Endotelina A / Antagonistas do Receptor de Endotelina B / Modelos Biológicos Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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