Structural Optimization of Indole Derivatives Acting at Colchicine Binding Site as Potential Anticancer Agents.

Hwang, Dong-Jin; Wang, Jin; Li, Wei; Miller, Duane D.

Afiliação

Hwang DJ; Department of Pharmaceutical Sciences, University of Tennessee, Health Science Center , Memphis, Tennessee 38163, United States.
Wang J; Department of Pharmaceutical Sciences, University of Tennessee, Health Science Center , Memphis, Tennessee 38163, United States.
Li W; Department of Pharmaceutical Sciences, University of Tennessee, Health Science Center , Memphis, Tennessee 38163, United States.
Miller DD; Department of Pharmaceutical Sciences, University of Tennessee, Health Science Center , Memphis, Tennessee 38163, United States.

ACS Med Chem Lett ; 6(9): 993-7, 2015 Sep 10.

Article em En | MEDLINE | ID: mdl-26396686

Palavras-chave

Colchicine-binding site; antiproliferative activity; liver microsomal stability; melanoma; multiple drug resistance; prostate cancer; structure−activity relationship (SAR); tubulin polymerization inhibitor

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2015 Tipo de documento: Article