Substrate modulus of 3D-printed scaffolds regulates the regenerative response in subcutaneous implants through the macrophage phenotype and Wnt signaling.

Guo, R; Merkel, A R; Sterling, J A; Davidson, J M; Guelcher, S A

Guo, R; Merkel, A R; Sterling, J A; Davidson, J M; Guelcher, S A.

Afiliação

Guo R; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37235, USA.
Merkel AR; Research Service, Department of Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN 37212, USA; Center for Bone Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nas
Sterling JA; Research Service, Department of Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN 37212, USA; Center for Bone Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nas
Davidson JM; Research Service, Department of Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN 37212, USA; Department of Pathology, Immunology, and Microbiology, Vanderbilt University, Nashville, TN 37232, USA.
Guelcher SA; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37235, USA; Center for Bone Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA. Electronic address: sc

Biomaterials ; 73: 85-95, 2015 Dec.

Article em En | MEDLINE | ID: mdl-26406449

Assuntos

Macrófagos/patologia; Regeneração/fisiologia; Alicerces Teciduais/química; Via de Sinalização Wnt; Animais; Células Cultivadas; Colágeno/química; Regulação para Baixo; Fibroblastos/metabolismo; Humanos; Peptídeos e Proteínas de Sinalização Intercelular/metabolismo; Cinética; Masculino; Neovascularização Patológica; Fenótipo; Porosidade; Pressão; Impressão Tridimensional; Ratos; Ratos Sprague-Dawley; Engenharia Tecidual; Proteínas Wnt/metabolismo; Cicatrização; beta Catenina/metabolismo

Palavras-chave

Elastic modulus; Fibroblast; Macrophage polarization; Scaffold; Wnt signaling; Wound healing

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regeneração / Alicerces Teciduais / Via de Sinalização Wnt / Macrófagos Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google