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Increased deoxythymidine triphosphate levels is a feature of relative cognitive decline.
Desler, Claus; Frederiksen, Jane H; Angleys, Maria; Maynard, Scott; Keijzers, Guido; Fagerlund, Birgitte; Mortensen, Erik Lykke; Osler, Merete; Lauritzen, Martin; Bohr, Vilhelm A; Rasmussen, Lene Juel.
Afiliação
  • Desler C; Center for Healthy Aging, Denmark; Department of Cellular and Molecular Medicine, University of Copenhagen, Denmark.
  • Frederiksen JH; Center for Healthy Aging, Denmark; Department of Cellular and Molecular Medicine, University of Copenhagen, Denmark.
  • Angleys M; Center for Healthy Aging, Denmark; Department of Cellular and Molecular Medicine, University of Copenhagen, Denmark.
  • Maynard S; Center for Healthy Aging, Denmark; Department of Cellular and Molecular Medicine, University of Copenhagen, Denmark.
  • Keijzers G; Center for Healthy Aging, Denmark; Department of Cellular and Molecular Medicine, University of Copenhagen, Denmark.
  • Fagerlund B; Center for Healthy Aging, Denmark; Lundbeck Foundation Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Center for Neuropsychiatric Schizophrenia Research (CNSR), Mental Health Centre Glostrup, Denmark.
  • Mortensen EL; Center for Healthy Aging, Denmark; Department of Public Health, University of Copenhagen, Denmark.
  • Osler M; Department of Public Health, University of Copenhagen, Denmark; Research Center for Prevention and Health, Glostrup Hospital, Glostrup, Denmark.
  • Lauritzen M; Center for Healthy Aging, Denmark; Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen N, Denmark; Department of Clinical Neurophysiology, Glostrup Hospital, Glostrup, Denmark.
  • Bohr VA; Center for Healthy Aging, Denmark; Laboratory of Molecular Gerontology, National Institutes on Aging, NIH, United States.
  • Rasmussen LJ; Center for Healthy Aging, Denmark; Department of Cellular and Molecular Medicine, University of Copenhagen, Denmark. Electronic address: lenera@sund.ku.dk.
Mitochondrion ; 25: 34-7, 2015 Nov.
Article em En | MEDLINE | ID: mdl-26408413
ABSTRACT
Mitochondrial bioenergetics, mitochondrial reactive oxygen species (ROS) and cellular levels of nucleotides have been hypothesized as early indicators of Alzheimer's disease (AD). Utilizing relative decline of cognitive ability as a predictor of AD risk, we evaluated the correlation between change of cognitive ability and mitochondrial bioenergetics, ROS and cellular levels of deoxyribonucleotides. Change of cognitive abilities, scored at ages of approximately 20 and 57 was determined for a cohort of 1985 male participants. Mitochondrial bioenergetics, mitochondrial ROS and whole-cell levels of deoxyribonucleotide triphosphates were measured in peripheral blood mononuclear cells (PBMCs) from a total of 103 selected participants displaying the most pronounced relative cognitive decline and relative cognitive improvement. We show that relative cognitive decline is associated with higher PBMC content of deoxythymidine-triphosphate (dTTP) (20%), but not mitochondrial bioenergetics parameters measured in this study or mitochondrial ROS. Levels of dTTP in PBMCs are indicators of relative cognitive change suggesting a role of deoxyribonucleotides in the etiology of AD.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nucleotídeos de Timina / Leucócitos Mononucleares / Espécies Reativas de Oxigênio / Metabolismo Energético / Doença de Alzheimer / Mitocôndrias Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nucleotídeos de Timina / Leucócitos Mononucleares / Espécies Reativas de Oxigênio / Metabolismo Energético / Doença de Alzheimer / Mitocôndrias Idioma: En Ano de publicação: 2015 Tipo de documento: Article