The AMPK activator R419 improves exercise capacity and skeletal muscle insulin sensitivity in obese mice.
Mol Metab
; 4(9): 643-51, 2015 Sep.
Article
em En
| MEDLINE
| ID: mdl-26413470
2-DG, 2-deoxyglucose; ACC, acetyl-CoA carboxylase; AICAR, 5-aminoimidazole-4-carboxamide-1-ß-d-ribofuranoside; AMPK; AMPK, AMP-activated protein kinase; AMPK-MKO, skeletal muscle-specific AMPK ß1ß2 floxed Cre-; AUC, area under the curve; COX, cytochrome c oxidase; CT, computed tomography; Complex-I; Diabetes; EDL, extensor digitorum longus; Exercise-mimetic; GDR, glucose disposal rate; GIR, glucose infusion rate; GLUT4, glucose transporter 4; HFD, high-fat diet (45% kcal fat); HGO, hepatic glucose output; Mitochondrial; OXPHOS, proteins involved in oxidative phosphorylation (electron transport chain); Obesity; R419; R419, N-(1-(4-cyanobenzyl) piperidin-4-yl)-6-(4-(4-methoxybenzoyl) piperidine-1-carbonyl; TA, tibialis anterior; Tbp, TATA-binding protein; WT, wildtype
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