Rotenone-induced Impairment of Mitochondrial Electron Transport Chain Confers a Selective Priming Signal for NLRP3 Inflammasome Activation.

Won, Ji-Hee; Park, Sangjun; Hong, Sujeong; Son, Seunghwan; Yu, Je-Wook

Won, Ji-Hee; Park, Sangjun; Hong, Sujeong; Son, Seunghwan; Yu, Je-Wook.

Afiliação

Won JH; Department of Microbiology, Institute for Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Korea.
Park S; Department of Microbiology, Institute for Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Korea.
Hong S; Department of Microbiology, Institute for Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Korea.
Son S; Department of Microbiology, Institute for Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Korea.
Yu JW; Department of Microbiology, Institute for Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Korea. Electronic address: Jewookyu@yuhs.ac.

J Biol Chem ; 290(45): 27425-27437, 2015 Nov 06.

Article em En | MEDLINE | ID: mdl-26416893

Assuntos

Proteínas de Transporte/metabolismo; Complexo de Proteínas da Cadeia de Transporte de Elétrons/antagonistas & inibidores; Inflamassomos/efeitos dos fármacos; Inflamassomos/metabolismo; Mitocôndrias/efeitos dos fármacos; Mitocôndrias/metabolismo; Rotenona/farmacologia; Desacopladores/farmacologia; Trifosfato de Adenosina/metabolismo; Animais; Proteínas de Transporte/genética; Caspase 1/metabolismo; Células Cultivadas; DNA Mitocondrial/metabolismo; Transporte de Elétrons/efeitos dos fármacos; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Proteína 3 que Contém Domínio de Pirina da Família NLR; Espécies Reativas de Oxigênio/metabolismo

Palavras-chave

NLRP3; inflammasome; innate immunity; mitochondrial dysfunction; mitochondrial respiratory chain complex; reactive oxygen species (ROS)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Rotenona / Desacopladores / Proteínas de Transporte / Complexo de Proteínas da Cadeia de Transporte de Elétrons / Inflamassomos / Mitocôndrias Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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