Bridging the translational divide: identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene.
Sci Rep
; 5: 14613, 2015 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-26423861
ABSTRACT
Development of effective therapies for brain disorders has been hampered by a lack of translational cognitive testing methods. We present the first example of using the identical touchscreen-based cognitive test to assess mice and humans carrying disease-related genetic mutations. This new paradigm has significant implications for improving how we measure and model cognitive dysfunction in human disorders in animals, thus bridging the gap towards effective translation to the clinic.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transtornos Cognitivos
/
Proteínas Supressoras de Tumor
/
Guanilato Quinases
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article