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Poly(ADP-ribosyl)ation of FOXP3 Protein Mediated by PARP-1 Protein Regulates the Function of Regulatory T Cells.
Luo, Xuerui; Nie, Jia; Wang, Shuaiwei; Chen, Zuojia; Chen, WanJun; Li, Dan; Hu, Hui; Li, Bin.
Afiliação
  • Luo X; From the Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
  • Nie J; From the Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
  • Wang S; From the Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
  • Chen Z; From the Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
  • Chen W; the Mucosal Immunology Section, Oral and Pharyngeal Cancer Branch, NIDCR, National Institutes of Health, Bethesda, Maryland, 20892-2190.
  • Li D; From the Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
  • Hu H; the Department of Microbiology, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294-2170.
  • Li B; From the Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China, binli@sibs.ac.cn.
J Biol Chem ; 290(48): 28675-82, 2015 Nov 27.
Article em En | MEDLINE | ID: mdl-26429911
ABSTRACT
Poly(ADP-ribose) polymerase 1 (PARP-1) is an ADP-ribosylating enzyme participating in diverse cellular functions. The roles of PARP-1 in the immune system, however, have not been well understood. Here we find that PARP-1 interacts with FOXP3 and induces its poly(ADP-ribosyl)ation. By using PARP-1 inhibitors, we show that reduced poly(ADP-ribosyl)ation of FOXP3 results in not only FOXP3 stabilization and increased FOXP3 downstream genes but also enhanced suppressive function of regulatory T cells. Our results suggest that PARP-1 negatively regulates the suppressive function of Treg cells at the posttranslational level via FOXP3 poly(ADP-ribosyl)ation. This finding has implications for developing PARP-1 inhibitors as potential agents for the prevention and treatment of autoimmune diseases.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Poli Adenosina Difosfato Ribose / Processamento de Proteína Pós-Traducional / Poli(ADP-Ribose) Polimerases / Linfócitos T Reguladores / Fatores de Transcrição Forkhead Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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XML
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Poli Adenosina Difosfato Ribose / Processamento de Proteína Pós-Traducional / Poli(ADP-Ribose) Polimerases / Linfócitos T Reguladores / Fatores de Transcrição Forkhead Idioma: En Ano de publicação: 2015 Tipo de documento: Article