IL-10 gene transfer upregulates arcuate POMC and ameliorates hyperphagia, obesity and diabetes by substituting for leptin.

Nakata, M; Yamamoto, S; Okada, T; Gantulga, D; Okano, H; Ozawa, K; Yada, T

Nakata, M; Yamamoto, S; Okada, T; Gantulga, D; Okano, H; Ozawa, K; Yada, T.

Afiliação

Nakata M; Department of Physiology, Division of Integrative Physiology, Jichi Medical University School of Medicine, Shimotsuke, Japan.
Yamamoto S; Department of Physiology, Division of Integrative Physiology, Jichi Medical University School of Medicine, Shimotsuke, Japan.
Okada T; Division of Genetic Therapeutics, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Japan.
Gantulga D; Department of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo, Japan.
Okano H; Department of Physiology, Division of Integrative Physiology, Jichi Medical University School of Medicine, Shimotsuke, Japan.
Ozawa K; Department of Physiology, Keio University School of Medicine, Tokyo, Japan.
Yada T; Division of Genetic Therapeutics, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Japan.

Int J Obes (Lond) ; 40(3): 425-33, 2016 Mar.

Article em En | MEDLINE | ID: mdl-26435324

Assuntos

Núcleo Arqueado do Hipotálamo/metabolismo; Diabetes Mellitus/patologia; Hiperfagia/patologia; Interleucina-10/metabolismo; Obesidade/patologia; Pró-Opiomelanocortina/metabolismo; Animais; Modelos Animais de Doenças; Metabolismo Energético; Técnicas de Transferência de Genes; Leptina; Masculino; Camundongos; Regulação para Cima

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Núcleo Arqueado do Hipotálamo / Pró-Opiomelanocortina / Hiperfagia / Interleucina-10 / Diabetes Mellitus / Obesidade Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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