Therapeutic Approaches to Inherited Optic Neuropathies.
Semin Neurol
; 35(5): 578-86, 2015 Oct.
Article
em En
| MEDLINE
| ID: mdl-26444403
ABSTRACT
As a group, inherited optic neuropathies represent an important cause of severe irreversible visual loss among children and young adults. Leber hereditary optic neuropathy (LHON) and autosomal dominant optic atrophy (DOA) are the two most common forms encountered in clinical practice and several shared disease pathways have emerged that contribute to retinal ganglion cell loss, and eventually visual failure. In this review, the author critically appraises the evidence base for the various therapeutic strategies that have been put forward to treat these two mitochondrially determined optic neuropathies, including future developments. Innovative in vitro fertilization techniques to prevent female carriers of childbearing age from transmitting pathogenic mitochondrial DNA mutations to their biological children will also be discussed.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Atrofia Óptica Hereditária de Leber
/
Atrofia Óptica Autossômica Dominante
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article