The pharmacokinetics of lopinavir/ritonavir when given with isoniazid in South African HIV-infected individuals.
Int J Tuberc Lung Dis
; 19(10): 1194-6, 2015 Oct.
Article
em En
| MEDLINE
| ID: mdl-26459532
ABSTRACT
Isoniazid preventive therapy is recommended in patients on antiretroviral treatment (ART) with latent tuberculous infection to prevent progression to active tuberculosis disease. Isoniazid (INH) inhibits cytochrome (CY) P3A4, which metabolises lopinavir (LPV). The administration of INH may cause higher LPV concentrations, which may increase LPV toxicity. LPV bioavailability is increased by co-formulated ritonavir (r), which may enhance the interaction of INH on LPV. We studied the effect of INH on LPV concentrations by administering INH for 7 days and performing intensive pharmacokinetic sampling in 16 human immunodeficiency virus infected patients established on LPV/r-based ART. INH did not significantly increase steady-state LPV area under the plasma concentration-time curve calculated for the 12 h-dosing interval.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ritonavir
/
Fármacos Anti-HIV
/
Lopinavir
/
Isoniazida
/
Antituberculosos
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article