Accurate and precise plasma clearance measurement using four 99mTc-DTPA plasma samples over 4 h.
Nucl Med Commun
; 37(1): 79-86, 2016 Jan.
Article
em En
| MEDLINE
| ID: mdl-26465802
ABSTRACT
OBJECTIVES:
Glomerular filtration rate can be measured as the plasma clearance (CL) of a glomerular filtration rate marker despite body fluid disturbances using numerous, prolonged time samples. We desire a simplified technique without compromised accuracy and precision. MATERIALS ANDMETHODS:
We compared CL values derived from two plasma concentration curve area methods - (a) biexponential fitting [CL (E2)] and (b) Tikhonov adaptively regularized gamma variate fitting [CL (Tk-GV)] - for 4 versus 8 h time samplings from 412 Tc-DTPA studies in 142 patients, mostly paediatric patients, with suspected fluid disturbances.RESULTS:
CL (Tk-GV) from four samples/4 h and from nine samples/8 h, both accurately and precisely agreed with the standard, which was taken to be nine samples/8 h CL from (noncompartmental) numerical integration [CL (NI)]. The E2 method, four samples/4 h, and nine samples/8 h median CL values significantly overestimated the CL (NI) values by 4.9 and 3.8%, respectively.CONCLUSION:
Compared with the standard, CL (E2) from four samples/4 h and from nine samples/8 h proved to be the most inaccurate and imprecise method examined, and can be replaced by better methods for calculating CL. The CL (Tk-GV) can be used to reduce sampling time in half from 8 to 4 h and from nine to four samples for a precise and accurate, yet more easily tolerated and simplified test.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Pentetato de Tecnécio Tc 99m
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article