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Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation.
Wu, Ming-Yu; Esteban, Gerard; Brogi, Simone; Shionoya, Masahi; Wang, Li; Campiani, Giuseppe; Unzeta, Mercedes; Inokuchi, Tsutomu; Butini, Stefania; Marco-Contelles, Jose.
Afiliação
  • Wu MY; Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University, 3.1.1 Tsushima-Naka, Kita-ku, Okayama 700-8530, Japan.
  • Esteban G; Departament de Bioquímica i Biologia Molecular, Facultat de Medicina, Institut de Neurociències, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain.
  • Brogi S; European Research Centre for Drug Discovery and Development (NatSynDrugs) and Department of Biotechnology, Chemistry and Pharmacy, Università degli Studi di Siena, Via A. Moro, 53100 Siena, Italy.
  • Shionoya M; Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University, 3.1.1 Tsushima-Naka, Kita-ku, Okayama 700-8530, Japan.
  • Wang L; Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University, 3.1.1 Tsushima-Naka, Kita-ku, Okayama 700-8530, Japan.
  • Campiani G; European Research Centre for Drug Discovery and Development (NatSynDrugs) and Department of Biotechnology, Chemistry and Pharmacy, Università degli Studi di Siena, Via A. Moro, 53100 Siena, Italy.
  • Unzeta M; Departament de Bioquímica i Biologia Molecular, Facultat de Medicina, Institut de Neurociències, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain. Electronic address: mercedes.unzeta@uab.cat.
  • Inokuchi T; Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University, 3.1.1 Tsushima-Naka, Kita-ku, Okayama 700-8530, Japan. Electronic address: inokuchi@cc.okayama-u.ac.jp.
  • Butini S; European Research Centre for Drug Discovery and Development (NatSynDrugs) and Department of Biotechnology, Chemistry and Pharmacy, Università degli Studi di Siena, Via A. Moro, 53100 Siena, Italy. Electronic address: butini3@unisi.it.
  • Marco-Contelles J; Laboratory of Medicinal Chemistry (IQOG, CSIC), C/Juan de la Cierva 3, 28006 Madrid, Spain. Electronic address: iqoc21@iqog.csic.es.
Eur J Med Chem ; 121: 864-879, 2016 Oct 04.
Article em En | MEDLINE | ID: mdl-26471320
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperidinas / Acetilcolinesterase / Desenho de Fármacos / Simulação de Acoplamento Molecular / Indanos / Monoaminoxidase Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperidinas / Acetilcolinesterase / Desenho de Fármacos / Simulação de Acoplamento Molecular / Indanos / Monoaminoxidase Idioma: En Ano de publicação: 2016 Tipo de documento: Article