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The influence of comorbid disorders on the episodicity of bipolar disorder in youth.
Yen, S; Stout, R; Hower, H; Killam, M A; Weinstock, L M; Topor, D R; Dickstein, D P; Hunt, J I; Gill, M K; Goldstein, T R; Goldstein, B I; Ryan, N D; Strober, M; Sala, R; Axelson, D A; Birmaher, B; Keller, M B.
Afiliação
  • Yen S; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, USA.
  • Stout R; Butler Hospital, Providence, RI, USA.
  • Hower H; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, USA.
  • Killam MA; Pacific Institute for Research and Evaluation, Pawtucket, RI, USA.
  • Weinstock LM; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, USA.
  • Topor DR; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, USA.
  • Dickstein DP; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, USA.
  • Hunt JI; Butler Hospital, Providence, RI, USA.
  • Gill MK; VA Boston Healthcare System and Harvard Medical School, Cambridge, MA, USA.
  • Goldstein TR; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, USA.
  • Goldstein BI; Emma Pendleton Bradley Hospital, East Providence, RI, USA.
  • Ryan ND; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, USA.
  • Strober M; Emma Pendleton Bradley Hospital, East Providence, RI, USA.
  • Sala R; Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
  • Axelson DA; Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
  • Birmaher B; Centre for Youth Bipolar Disorder, University of Toronto Medical Center, Toronto, ON, Canada.
  • Keller MB; Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Acta Psychiatr Scand ; 133(4): 324-34, 2016 Apr.
Article em En | MEDLINE | ID: mdl-26475572
ABSTRACT

OBJECTIVE:

Bipolar disorder (BP) frequently co-occurs with other psychiatric disorders. We examine whether course of anxiety disorders (ANX), attention deficit hyperactivity disorder (ADHD), disruptive behavior disorders (DBD), and substance use disorders (SUD) influence likelihood of recovery and recurrence of depression and mania in BP youth.

METHOD:

Weekly ratings of psychiatric disorder intensity were obtained from 413 participants of the Course and Outcome of BP Youth project, followed for an average of 7.75 years. Multiple-event Cox proportional hazards regression analyses examined worsening of comorbid disorders as predictors of mood episode recovery and recurrence.

RESULTS:

Increased severity in ANX and SUD predicted longer time to recovery and less time to next depressive episode, and less time to next manic episode. Multivariate models with ANX and SUD found that significant effects of ANX remained, but SUD only predicted longer time to depression recovery. Increased severity of ADHD and DBD predicted shorter time to recurrence for depressive and manic episodes.

CONCLUSION:

There are significant time-varying relationships between the course of comorbid disorders and episodicity of depression and mania in BP youth. Worsening of comorbid conditions may present as a precursor to mood episode recurrence or warn of mood episode protraction.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtornos de Ansiedade / Transtorno do Deficit de Atenção com Hiperatividade / Transtorno Bipolar / Transtornos de Deficit da Atenção e do Comportamento Disruptivo / Transtornos Relacionados ao Uso de Substâncias Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtornos de Ansiedade / Transtorno do Deficit de Atenção com Hiperatividade / Transtorno Bipolar / Transtornos de Deficit da Atenção e do Comportamento Disruptivo / Transtornos Relacionados ao Uso de Substâncias Idioma: En Ano de publicação: 2016 Tipo de documento: Article