Inflammation (or synovitis)-driven osteoarthritis: an opportunity for personalizing prognosis and treatment?
Scand J Rheumatol
; 45(2): 87-98, 2016.
Article
em En
| MEDLINE
| ID: mdl-26484849
ABSTRACT
The disabling and painful disease osteoarthritis (OA) is the most common form of arthritis. Strong evidence suggests that a subpopulation of OA patients has a form of OA driven by inflammation. Consequently, understanding when inflammation is the driver of disease progression and which OA patients might benefit from anti-inflammatory treatment is a topic of intense research in the OA field. We have reviewed the current literature on OA, with an emphasis on inflammation in OA, biochemical markers of structural damage, and anti-inflammatory treatments for OA. The literature suggests that the OA patient population is diverse, consisting of several subpopulations, including one associated with inflammation. This inflammatory subpopulation may be identified by a combination of novel serological inflammatory biomarkers. Preliminary evidence from small clinical studies suggests that this subpopulation may benefit from anti-inflammatory treatment currently reserved for other inflammatory arthritides.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Osteoartrite
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Membrana Sinovial
/
Sinovite
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Cartilagem Articular
/
Antirreumáticos
/
Medicina de Precisão
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article