Comparative trial of Aloe vera/olive oil combination cream versus phenytoin cream in the treatment of chronic wounds.
J Wound Care
; 24(10): 459-60, 462-5, 2015 Oct.
Article
em En
| MEDLINE
| ID: mdl-26488737
ABSTRACT
OBJECTIVE:
Aloe vera is a medicinal plant that has been traditionally used to accelerate wound healing. Olive oil is also a natural product that may contribute to wound healing owing to its antimicrobial and anti-inflammatory effects. The present study aimed to evaluate the effect of an Aloe vera-olive oil (AVO) combination cream on the healing process of chronic wounds.METHOD:
In this randomised, double-blind, comparator-controlled, parallel-group trial, patients with chronic wounds were treated with either AVO cream or phenytoin cream as the standard treatment for a period of 30 days. Wound healing was evaluated using Bates-Jensen assessment tool and the severity of pain was assessed using a visual analogue scale (VAS).RESULTS:
After initial assessment, 60 patients with chronic wounds (41 with pressure ulcer, 13 with diabetic wounds and 6 with venous ulcers), were recruited and randomised into 2 groups of 30. After 30 days of treatment, significant improvements in the wound size, depth, and edges; necrotic tissue type and amount; exudate type and amount; colour of wound surroundings; and peripheral tissue oedema score were observed in the AVO cream group (p<0.001). The total score of wound healing showed significant improvement with both AVO (p<0.001) and phenytoin (p<0.01) creams, although AVO was more efficacious (p<0.001). Likewise, although both treatments reduced the initial VAS score, the efficacy of AVO was significantly greater (p<0.001).CONCLUSION:
AVO cream significantly accelerates biological healing of chronic wounds and helps to reduce pain severity with a higher efficacy compared with phenytoin cream.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Dor
/
Fenitoína
/
Cicatrização
/
Ferimentos e Lesões
/
Preparações de Plantas
/
Azeite de Oliva
/
Fitoterapia
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article