Diagnostic markers of axonal degeneration and demyelination in sensory nerve conduction.
Muscle Nerve
; 53(6): 866-71, 2016 06.
Article
em En
| MEDLINE
| ID: mdl-26501987
ABSTRACT
INTRODUCTION:
The aim of this study was to formulate diagnostic hallmarks of axonal degeneration and demyelination in sensory nerve conduction studies (NCS).METHODS:
We compared nerve conduction data obtained with surface electrode (SE) NCS and on-nerve needle (ONN) NCS in 50 cases of demyelination and 22 cases of axonal degeneration as assessed by sural nerve biopsy.RESULTS:
The overall diagnostic sensitivities of sensory nerve conduction were 26% by SE-NCS and 69% by ONN-NCS. The most helpful marker for demyelination was negative-peak nerve conduction velocity (NP-NCV), using a 36% decrease from the means in both techniques. Dispersion was also helpful in identifying demyelination. Low amplitude and absence of compound nerve action potential were indicative of general pathology in SE-NCS but of axonal degeneration in ONN-NCS.CONCLUSION:
Although diagnostic sensitivity is low, NP-NCV and dispersion can be used for diagnosis of demyelination in sensory NCS. Muscle Nerve 53 866-871, 2016.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Nervo Sural
/
Doenças Desmielinizantes
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Degeneração Neural
/
Condução Nervosa
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article