An update on transcriptional and post-translational regulation of brain voltage-gated sodium channels.
Amino Acids
; 48(3): 641-651, 2016 Mar.
Article
em En
| MEDLINE
| ID: mdl-26503606
ABSTRACT
Voltage-gated sodium channels are essential proteins in brain physiology, as they generate the sodium currents that initiate neuronal action potentials. Voltage-gated sodium channels expression, localisation and function are regulated by a range of transcriptional and post-translational mechanisms. Here, we review our understanding of regulation of brain voltage-gated sodium channels, in particular SCN1A (NaV1.1), SCN2A (NaV1.2), SCN3A (NaV1.3) and SCN8A (NaV1.6), by transcription factors, by alternative splicing, and by post-translational modifications. Our focus is strongly centred on recent research lines, and newly generated knowledge.
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MEDLINE
Assunto principal:
Transcrição Gênica
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Encéfalo
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Processamento de Proteína Pós-Traducional
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Canais de Sódio Disparados por Voltagem
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article