Topical sulfasalazine for unresponsive oral lichen planus.
Quintessence Int
; 47(4): 319-27, 2016 Apr.
Article
em En
| MEDLINE
| ID: mdl-26504904
ABSTRACT
OBJECTIVE:
The purpose of this study was to evaluate the usefulness of topical sulfasalazine in the treatment of oral lichen planus (OLP) resistant to corticosteroid therapy. METHOD AND MATERIALS Twenty-one unresponsive OLP patients were treated with topical sulfasalazine 3 times a day for 4 weeks. Each patient's symptoms and lesion size were evaluated at the beginning of therapy, and then after 4 weeks to determine the efficacy of topical sulfasalazine. Inflammatory cytokines levels in saliva were measured by ELISA.RESULTS:
Seventeen patients (81%) reported improvement of discomfort and 12 patients (57%) had lesions decrease in size over 50%. Patients who had higher levels of IL-1ß and IL-8 were more responsive to topical sulfasalazine therapy.CONCLUSION:
Topical sulfasalazine should be considered when OLP does not respond to corticosteroid therapy. Furthermore, high concentrations of IL-1ß and IL-8 in the saliva are useful indicators for the application of topical sulfasalazine in OLP patients refractory to steroid treatment.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sulfassalazina
/
Líquen Plano Bucal
/
Anti-Infecciosos
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article