Stereoselective Total Synthesis of (-)-Depudecin.
Org Lett
; 17(22): 5558-61, 2015 Nov 20.
Article
em En
| MEDLINE
| ID: mdl-26517569
ABSTRACT
The total synthesis of the natural product depudecin, an antiangiogenic microbial polyketide with inhibitory activity against histone deacetylases, is reported. Characterized by a highly oxidized 11-carbon chain containing two epoxides conjugated through a trans-disubstituted olefin, its total synthesis was efficiently accomplished by a novel asymmetric methodology of epoxide formation based on a new class of chiral sulfonium salts, allowing for the construction of the oxirane rings in an efficient and stereoselective fashion.
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1
Base de dados:
MEDLINE
Assunto principal:
Produtos Biológicos
/
Alcadienos
/
Compostos de Epóxi
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Álcoois Graxos
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article