Doxorubicin causes transient activation of protein poly(ADP-ribosyl)ation in H9c2 cardiomyocytes.
Dokl Biochem Biophys
; 464: 333-7, 2015.
Article
em En
| MEDLINE
| ID: mdl-26518562
ABSTRACT
Possible involvement of the system of protein poly(ADP-ribosyl)ation in the mechanisms of cardiotoxicity of doxorubicin, one of the most frequently used anticancer drug, was studied in cultures of cardiomyocytes H9c2. The treatment of H9c2 cells with doxorubicin (1 µM) led to a transient (after 6 h of incubation) increase in the nuclear level of poly(ADP-ribosyl)ated proteins. The observed data indirectly indicate the development of genotoxic stress in the doxorubicin-treated cells, probably caused by the stimulatory effects of doxorubicin and its metabolites on the production of reactive oxygen and nitrogen species.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doxorrubicina
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Poli(ADP-Ribose) Polimerases
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Ativadores de Enzimas
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Miócitos Cardíacos
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Antibióticos Antineoplásicos
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article