Sialomes and Mialomes: A Systems-Biology View of Tick Tissues and Tick-Host Interactions.
Trends Parasitol
; 32(3): 242-254, 2016 Mar.
Article
em En
| MEDLINE
| ID: mdl-26520005
ABSTRACT
Tick saliva facilitates tick feeding and infection of the host. Gene expression analysis of tick salivary glands and other tissues involved in host-pathogen interactions has revealed a wide range of bioactive tick proteins. Transcriptomic analysis has been a milestone in the field and has recently been enhanced by next-generation sequencing (NGS). Furthermore, the application of quantitative proteomics to ticks with unknown genomes has provided deeper insights into the molecular mechanisms underlying tick hematophagy, pathogen transmission, and tick-host-pathogen interactions. We review current knowledge on the transcriptomics and proteomics of tick tissues from a systems-biology perspective and discuss future challenges in the field.
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Base de dados:
MEDLINE
Assunto principal:
Carrapatos
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Proteoma
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Biologia de Sistemas
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Transcriptoma
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Interações Hospedeiro-Parasita
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article