Formal Direct Cross-Coupling of Phenols with Amines.
Angew Chem Int Ed Engl
; 54(48): 14487-91, 2015 Nov 23.
Article
em En
| MEDLINE
| ID: mdl-26531683
ABSTRACT
The transition-metal-catalyzed amination of aryl halides has been the most powerful method for the formation of aryl amines over the past decades. Phenols are regarded as ideal alternatives to aryl halides as coupling partners in cross-couplings. An efficient palladium-catalyzed formal cross-coupling of phenols with various amines and anilines has now been developed. A variety of substituted phenols were compatible with the standard reaction conditions. Secondary and tertiary aryl amines could thus be synthesized in moderate to excellent yields.
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MEDLINE
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En
Ano de publicação:
2015
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Article