Perfluoroalkylchain conjugation as a new tactic for enhancing cell permeability of peptide nucleic acids (PNAs) via reducing the nanoparticle size.
Chem Commun (Camb)
; 52(3): 521-4, 2016 Jan 11.
Article
em En
| MEDLINE
| ID: mdl-26535419
ABSTRACT
Perfluoro undecanoyl chain conjugated peptide nucleic acids (PNAs) show 2.5 to 3 fold higher cellular uptake efficiency in NIH 3T3 and HeLa cells compared to simple undecanoyl PNAs. Fluorination of PNAs leads to the formation of lower size (â¼100-250 nm) nanoparticles compared to larger size (â¼500 nm) nanoparticles from non-fluorinated PNAs, thereby improving the efficiency of cell penetration.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ácidos Nucleicos Peptídicos
/
Nanopartículas
/
Fluorocarbonos
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article