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GM2 Gangliosidosis Variant 0 (Sandhoff Disease) in a Mixed-Breed Dog.
Kohyama, Moeko; Yabuki, Akira; Kawasaki, Yasuaki; Kawaguchi, Hiroaki; Miura, Naoki; Kitano, Yoshiaki; Onitsuka, Toshinori; Rahman, Mohammad Mahbubur; Miyoshi, Noriaki; Yamato, Osamu.
Afiliação
  • Kohyama M; From the Laboratories of Clinical Pathology (M.K., A.Y., M.M.R., O.Y.), Behavioral Physiology and Ecology (Y.Ka.), Veterinary Histopathology (H.K., N.Miy.), and Diagnostic Imaging (N.Miu.) of the Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan; Kitano Animal Hospital, Iz
  • Yabuki A; From the Laboratories of Clinical Pathology (M.K., A.Y., M.M.R., O.Y.), Behavioral Physiology and Ecology (Y.Ka.), Veterinary Histopathology (H.K., N.Miy.), and Diagnostic Imaging (N.Miu.) of the Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan; Kitano Animal Hospital, Iz
  • Kawasaki Y; From the Laboratories of Clinical Pathology (M.K., A.Y., M.M.R., O.Y.), Behavioral Physiology and Ecology (Y.Ka.), Veterinary Histopathology (H.K., N.Miy.), and Diagnostic Imaging (N.Miu.) of the Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan; Kitano Animal Hospital, Iz
  • Kawaguchi H; From the Laboratories of Clinical Pathology (M.K., A.Y., M.M.R., O.Y.), Behavioral Physiology and Ecology (Y.Ka.), Veterinary Histopathology (H.K., N.Miy.), and Diagnostic Imaging (N.Miu.) of the Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan; Kitano Animal Hospital, Iz
  • Miura N; From the Laboratories of Clinical Pathology (M.K., A.Y., M.M.R., O.Y.), Behavioral Physiology and Ecology (Y.Ka.), Veterinary Histopathology (H.K., N.Miy.), and Diagnostic Imaging (N.Miu.) of the Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan; Kitano Animal Hospital, Iz
  • Kitano Y; From the Laboratories of Clinical Pathology (M.K., A.Y., M.M.R., O.Y.), Behavioral Physiology and Ecology (Y.Ka.), Veterinary Histopathology (H.K., N.Miy.), and Diagnostic Imaging (N.Miu.) of the Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan; Kitano Animal Hospital, Iz
  • Onitsuka T; From the Laboratories of Clinical Pathology (M.K., A.Y., M.M.R., O.Y.), Behavioral Physiology and Ecology (Y.Ka.), Veterinary Histopathology (H.K., N.Miy.), and Diagnostic Imaging (N.Miu.) of the Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan; Kitano Animal Hospital, Iz
  • Rahman MM; From the Laboratories of Clinical Pathology (M.K., A.Y., M.M.R., O.Y.), Behavioral Physiology and Ecology (Y.Ka.), Veterinary Histopathology (H.K., N.Miy.), and Diagnostic Imaging (N.Miu.) of the Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan; Kitano Animal Hospital, Iz
  • Miyoshi N; From the Laboratories of Clinical Pathology (M.K., A.Y., M.M.R., O.Y.), Behavioral Physiology and Ecology (Y.Ka.), Veterinary Histopathology (H.K., N.Miy.), and Diagnostic Imaging (N.Miu.) of the Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan; Kitano Animal Hospital, Iz
  • Yamato O; From the Laboratories of Clinical Pathology (M.K., A.Y., M.M.R., O.Y.), Behavioral Physiology and Ecology (Y.Ka.), Veterinary Histopathology (H.K., N.Miy.), and Diagnostic Imaging (N.Miu.) of the Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan; Kitano Animal Hospital, Iz
J Am Anim Hosp Assoc ; 51(6): 396-400, 2015.
Article em En | MEDLINE | ID: mdl-26535459
GM2 gangliosidosis variant 0 (Sandhoff disease, SD) is a fatal, progressive, neurodegenerative lysosomal storage disease caused by simultaneous deficiencies of acid ß-hexosaminidases A and B. Canine SD has so far been identified only in two purebreeds. In this article, we present the case of a 10 mo old, male dog of mixed breed that developed progressive neurological signs including ataxia, postural deficit, and visual deficits and finally died at the age of 21 mo. The dog was diagnosed with SD on the basis of the results of biochemical and histopathological analyses. This is the third report of canine SD and the first time it has been identified in a mixed breed.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Sandhoff / Doenças do Cão Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Sandhoff / Doenças do Cão Idioma: En Ano de publicação: 2015 Tipo de documento: Article