Mucosal delivery switches the response to an adjuvanted tuberculosis vaccine from systemic TH1 to tissue-resident TH17 responses without impacting the protective efficacy.

Orr, Mark T; Beebe, Elyse A; Hudson, Thomas E; Argilla, David; Huang, Po-Wei D; Reese, Valerie A; Fox, Christopher B; Reed, Steven G; Coler, Rhea N

Orr, Mark T; Beebe, Elyse A; Hudson, Thomas E; Argilla, David; Huang, Po-Wei D; Reese, Valerie A; Fox, Christopher B; Reed, Steven G; Coler, Rhea N.

Afiliação

Orr MT; Infectious Disease Research Institute, Seattle, WA 98102, USA; Department of Global Health, University of Washington, Seattle, WA 98105, USA. Electronic address: Mark.orr@idri.org.
Beebe EA; Infectious Disease Research Institute, Seattle, WA 98102, USA.
Hudson TE; Infectious Disease Research Institute, Seattle, WA 98102, USA.
Argilla D; Infectious Disease Research Institute, Seattle, WA 98102, USA.
Huang PW; Infectious Disease Research Institute, Seattle, WA 98102, USA.
Reese VA; Infectious Disease Research Institute, Seattle, WA 98102, USA.
Fox CB; Infectious Disease Research Institute, Seattle, WA 98102, USA; Department of Global Health, University of Washington, Seattle, WA 98105, USA.
Reed SG; Infectious Disease Research Institute, Seattle, WA 98102, USA; Department of Global Health, University of Washington, Seattle, WA 98105, USA.
Coler RN; Infectious Disease Research Institute, Seattle, WA 98102, USA; Department of Global Health, University of Washington, Seattle, WA 98105, USA.

Vaccine ; 33(48): 6570-8, 2015 Nov 27.

Article em En | MEDLINE | ID: mdl-26541135

Assuntos

Células Th1/imunologia; Células Th17/imunologia; Vacinas contra a Tuberculose/administração & dosagem; Vacinas contra a Tuberculose/imunologia; Tuberculose Pulmonar/prevenção & controle; Adjuvantes Imunológicos/administração & dosagem; Administração através da Mucosa; Animais; Antígenos de Bactérias/imunologia; Vacina BCG/imunologia; Linfócitos T CD4-Positivos/imunologia; Citocinas/metabolismo; Cobaias; Humanos; Camundongos; Mycobacterium tuberculosis/imunologia; Fragmentos de Peptídeos/imunologia; Fator de Necrose Tumoral alfa/imunologia

Palavras-chave

ID93+GLA-SEi; Intranasal; Mucosal; TH17; Tuberculosis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tuberculose Pulmonar / Células Th1 / Vacinas contra a Tuberculose / Células Th17 Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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