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A phase 1 clinical trial of the selective BTK inhibitor ONO/GS-4059 in relapsed and refractory mature B-cell malignancies.
Walter, Harriet S; Rule, Simon A; Dyer, Martin J S; Karlin, Lionel; Jones, Ceri; Cazin, Bruno; Quittet, Philippe; Shah, Nimish; Hutchinson, Claire V; Honda, Hideyuki; Duffy, Kevin; Birkett, Joseph; Jamieson, Virginia; Courtenay-Luck, Nigel; Yoshizawa, Toshio; Sharpe, John; Ohno, Tomoya; Abe, Shinichiro; Nishimura, Akihisa; Cartron, Guillaume; Morschhauser, Franck; Fegan, Christopher; Salles, Gilles.
Afiliação
  • Walter HS; Ernest and Helen Scott Haematological Research Institute, University of Leicester, Leicester, United Kingdom;
  • Rule SA; Department of Haematology, Plymouth Hospitals NHS Trust, Plymouth, United Kingdom;
  • Dyer MJ; Ernest and Helen Scott Haematological Research Institute, University of Leicester, Leicester, United Kingdom;
  • Karlin L; Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Service d'Hématologie, Pierre-Bénite, Université Claude Bernard Lyon 1, Lyon, France;
  • Jones C; Cardiff CLL Research Group, School of Medicine, Heath Park, Cardiff, Wales, United Kingdom;
  • Cazin B; Department of Clinical Hematology, Centre Hospitalier Régional Universitaire (CHRU) de Lille, and Unité Groupe de Recherche sur les Formes Injectables et les Technologies Associées (GRITA), Université de Lille 2, Lille, France;
  • Quittet P; Department of Clinical Hematology and Unité Mixte de Recherche (UMR)-Centre National de la Recherche Scientifique (CNRS) 5235, CHRU, Montpellier, France;
  • Shah N; Department of Haematology, Plymouth Hospitals NHS Trust, Plymouth, United Kingdom;
  • Hutchinson CV; Ernest and Helen Scott Haematological Research Institute, University of Leicester, Leicester, United Kingdom; Department of Haematology, Plymouth Hospitals NHS Trust, Plymouth, United Kingdom;
  • Honda H; ONO Pharmaceuticals Co Ltd, Osaka, Japan; and.
  • Duffy K; ONO Pharma UK Ltd, London, United Kingdom.
  • Birkett J; ONO Pharma UK Ltd, London, United Kingdom.
  • Jamieson V; ONO Pharma UK Ltd, London, United Kingdom.
  • Courtenay-Luck N; ONO Pharma UK Ltd, London, United Kingdom.
  • Yoshizawa T; ONO Pharmaceuticals Co Ltd, Osaka, Japan; and.
  • Sharpe J; ONO Pharma UK Ltd, London, United Kingdom.
  • Ohno T; ONO Pharmaceuticals Co Ltd, Osaka, Japan; and.
  • Abe S; ONO Pharma UK Ltd, London, United Kingdom.
  • Nishimura A; ONO Pharmaceuticals Co Ltd, Osaka, Japan; and.
  • Cartron G; Department of Clinical Hematology and Unité Mixte de Recherche (UMR)-Centre National de la Recherche Scientifique (CNRS) 5235, CHRU, Montpellier, France;
  • Morschhauser F; Department of Clinical Hematology, Centre Hospitalier Régional Universitaire (CHRU) de Lille, and Unité Groupe de Recherche sur les Formes Injectables et les Technologies Associées (GRITA), Université de Lille 2, Lille, France;
  • Fegan C; Cardiff CLL Research Group, School of Medicine, Heath Park, Cardiff, Wales, United Kingdom;
  • Salles G; Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Service d'Hématologie, Pierre-Bénite, Université Claude Bernard Lyon 1, Lyon, France;
Blood ; 127(4): 411-9, 2016 Jan 28.
Article em En | MEDLINE | ID: mdl-26542378
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Proteínas Tirosina Quinases / Linfócitos B / Leucemia Linfocítica Crônica de Células B / Linfoma Difuso de Grandes Células B / Linfoma de Célula do Manto / Inibidores de Proteínas Quinases / Imidazóis Idioma: En Ano de publicação: 2016 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Proteínas Tirosina Quinases / Linfócitos B / Leucemia Linfocítica Crônica de Células B / Linfoma Difuso de Grandes Células B / Linfoma de Célula do Manto / Inibidores de Proteínas Quinases / Imidazóis Idioma: En Ano de publicação: 2016 Tipo de documento: Article