Intraarterial administration of norcantharidin attenuates ischemic stroke damage in rodents when given at the time of reperfusion: novel uses of endovascular capabilities.

Khan, Imad S; Odom, Mitchell; Ehtesham, Moneeb; Colvin, Daniel; Quarles, C Chad; McLaughlin, BethAnn; Singer, Robert J

Khan, Imad S; Odom, Mitchell; Ehtesham, Moneeb; Colvin, Daniel; Quarles, C Chad; McLaughlin, BethAnn; Singer, Robert J.

Afiliação

Khan IS; J.B. Marshall Laboratory for Neurovascular Therapeutics at Dartmouth;
Odom M; Division of Neurosurgery, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire;
Ehtesham M; Department of Neurosurgery, Vanderbilt University Medical Center;
Colvin D; Department of Neurosurgery, Vanderbilt University Medical Center;
Quarles CC; Vanderbilt University Institute of Imaging Sciences; and.
McLaughlin B; Vanderbilt University Institute of Imaging Sciences; and.
Singer RJ; Department of Neurology and Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee.

J Neurosurg ; 125(1): 152-9, 2016 07.

Article em En | MEDLINE | ID: mdl-26544777

Assuntos

Isquemia Encefálica/prevenção & controle; Compostos Bicíclicos Heterocíclicos com Pontes/administração & dosagem; Inibidores de Metaloproteinases de Matriz/administração & dosagem; Acidente Vascular Cerebral/prevenção & controle; Animais; Isquemia Encefálica/etiologia; Isquemia Encefálica/patologia; Modelos Animais de Doenças; Injeções Intra-Arteriais; Masculino; Metaloproteinase 9 da Matriz; Ratos; Acidente Vascular Cerebral/etiologia; Acidente Vascular Cerebral/patologia

Palavras-chave

BBB = blood-brain barrier; DMSO = dimethyl sulfoxide; ICA = internal carotid artery; IV = intravenous; MCA = middle cerebral artery; MCAO = MCA occlusion; MMP-9; MMP-9 = matrix metalloprotease-9; NCTD = norcantharidin; VEGF = vascular endothelial growth factor; intraarterial therapy; ischemia reperfusion injury; neuroprotection; norcantharidin; stroke; tPA = tissue plasminogen activator; vascular disorders

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Isquemia Encefálica / Compostos Bicíclicos Heterocíclicos com Pontes / Acidente Vascular Cerebral / Inibidores de Metaloproteinases de Matriz Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google