Expansion of CD14(+)CD16(+) monocytes is related to acute leukemia.
Int J Clin Exp Med
; 8(8): 12297-306, 2015.
Article
em En
| MEDLINE
| ID: mdl-26550139
ABSTRACT
OBJECTIVE:
Aim to investigate the proportion of CD14(+)CD16(+) monocytes and understand the pathogenesis of this monocyte subset in acute leukemia.METHODS:
Flow cytometry was utilized to study the phenotype expression of CD14(+)CD16(+) monocytes and CD3(+) T lymphocytes in peripheral blood derived from patients with acute leukemia. All the data were analyzed by SPSS 13.0 software.RESULTS:
The proportion of CD14(+)CD16(+) monocytes including both intermediate and non-classical monocytes, increased significantly in patients with acute leukemia and changed negatively or positively according to the disease process. Meanwhile, the proportion of CD14(+)CD16(+) monocytes was inversely correlated with absolute number of CD4(+) T lymphocytes, ratio of CD4(+)/CD8(+) T cells, and positively correlated with the proportion of neutrophil granulocytes.CONCLUSIONS:
The proportion of CD14(+)CD16(+) monocytes (especially the intermediate subpopulation) is related to the progression of acute leukemia, and the expansion of this monocyte subset could indicate the severity of the disease.
Texto completo:
1
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article