A new triterpenoid saponin from Gleditsia sinensis and its antiproliferative activity.

ABSTRACT

Chemical investigation of the anomalous fruits of Gleditsia sinensis led to the isolation and identification of a new triterpenoid saponin, 3-O-ß-D-xylopyranosyl-(1 â†’ 2)-α-L-arabinopyranosyl-(1 â†’ 6)-ß-D-glucopyranosyl oleanolic acid 28-O-ß-D-xylopyranosyl-(1 â†’ 4)-α-L-rhamnopyrano--syl-(1 â†’ 4)-ß-D-xylopyranosyl-(1 â†’ 4)-α-L-rhamnopyranosyl-(1 â†’ 3)-ß-D-glucopyranosyl ester (1), along with other nine known compounds (2-10). All the isolates from this species were reported for the first time. The structure of Compound 1 was determined by a detailed analysis using various analytical techniques, including 1D and 2D NMR. In vitro antiproliferative activities of Compound 1 on MCF-7 and Hep-G2 tumor cell lines were evaluated. IC50 values against the two cell lines were 9.5 and 11.6 µM, respectively.