Synthesis of novel pyrophosphorothiolate-linked dinucleoside cap analogues in a ball mill.
Org Biomol Chem
; 14(4): 1201-5, 2016 Jan 28.
Article
em En
| MEDLINE
| ID: mdl-26565694
ABSTRACT
Michaelis-Arbuzov reactions of S-aryl disulfide derivatives of 3'-thiothymidine or 5'-thioadenosine with tris(trimethylsilyl) phosphite proceeded in high yields to the corresponding phosphorothiolate monoesters. Subsequent hydrolytic desilylation and phosphate coupling were effected in one-pot using liquid-assisted grinding in a vibration ball mill. Novel 3',5'- and 5',5'-pyrophosphorothiolate-linked dinucleoside cap analogues were thereby prepared.
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Base de dados:
MEDLINE
Assunto principal:
Compostos Organofosforados
/
Compostos de Sulfidrila
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Nucleotídeos
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article