Can a volume challenge pinpoint the limiting factor in a Fontan circulation?
Acta Cardiol
; 70(5): 536-42, 2015 Oct.
Article
em En
| MEDLINE
| ID: mdl-26567813
ABSTRACT
OBJECTIVE:
It is difficult to indicate whether the limitation in a failing Fontan circulation lies within the pulmonary vasculature or the heart. Such differentiation is crucial to direct adequate therapy. This study was set out to determine if a volume challenge could identify the limiting factor. METHODS AND STUDY POPULATION Thirty-two catheterizations in 28 patients with a Fontan circulation were included. Pressures and oxygen saturations were measured before and after volume challenge (NaCl 0.9%; 15 cc/Kg). The changes in data were grouped based on the location of the major pressure increase. Ventricular function was measured in the resting state.RESULTS:
The majority of the patients showed an increase in aortic oxygen saturation, mixed venous oxygen saturation, systolic, pulmonary and systemic venous pressures. The arterio-venous oxygen gradient decreased, suggesting an increase in cardiac output. Different patterns in pressure changes were observed. Most (n=17) showed a similar increase of ventricular end-diastolic pressure and mean venous pressure (MVP); some (n=7) showed a lower increase of MVP, suggesting pulmonary reserve and recruitment; others (n=8) showed a significant higher increase in MVP, suggesting increased pulmonary vascular resistance. All volume challenge was well tolerated.CONCLUSION:
Most patients were preload-responsive. The pressure changes following volume load showed patterns with a potential of differentiating between patients with a major pulmonary or cardiac limiting factor.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Volume Sanguíneo
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Cateterismo Cardíaco
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Cloreto de Sódio
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Circulação Pulmonar
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Técnica de Fontan
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Circulação Coronária
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article