Hexagonal-shaped chondroitin sulfate self-assemblies have exalted anti-HSV-2 activity.
Carbohydr Polym
; 136: 113-20, 2016 Jan 20.
Article
em En
| MEDLINE
| ID: mdl-26572336
ABSTRACT
The initial step in mucosal infection by the herpes simplex virus type 2 (HSV-2) requires its binding to certain glycosaminoglycans naturally present on host cell membranes. We took advantage of this interaction to design biomimetic supramolecular hexagonal-shaped nanoassemblies composed of chondroitin sulfate having exalted anti-HSV-2 activity in comparison with native chondroitin sulfate. Nanoassemblies were formed by mixing hydrophobically-modified chondroitin sulfate with α-cyclodextrin in water. Optimization of alkyl chain length grafted on chondroitin sulfate and the ratio between hydrophobically-modified chondroitin sulfate and α-cyclodextrin showed that more cohesive and well-structured nanoassemblies were obtained using higher α-cyclodextrin concentration and longer alkyl chain lengths. A structure-activity relationship was found between anti-HSV-2 activity and the amphiphilic nature of hydrophobically-modified chondroitin sulfate. Also, antiviral activity of hexagonal nanoassemblies against HSV-2 was further improved in comparison with hydrophobically-modified chondroitin sulfate. This work suggests a new biomimetic formulation approach that can be extended to other heparan-sulfate-dependent viruses.
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Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Sulfatos de Condroitina
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Herpesvirus Humano 2
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article