Highly selective, sensitive and fluorescent sensing of dimeric G-quadruplexes by a dimeric berberine.
Org Biomol Chem
; 14(1): 191-7, 2016 Jan 07.
Article
em En
| MEDLINE
| ID: mdl-26580142
ABSTRACT
This paper describes the highly selective, sensitive and topology-specific fluorescent sensing of dimeric G-quadruplexes by a polyether-tethered dimeric berberine 1. Compound 1 displays high selectivity for dimeric G-quadruplexes over monomeric ones, and can be lit up by dimeric G-quadruplexes, in particular by the one linked with one TTA subunit. In addition, it shows no effect on the topology or thermal stability of the G-quadruplexes.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Berberina
/
Quadruplex G
/
Fluorescência
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article