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The E3 ubiquitin ligase Idol controls brain LDL receptor expression, ApoE clearance, and Aß amyloidosis.
Choi, Jinkuk; Gao, Jie; Kim, Jaekwang; Hong, Cynthia; Kim, Jungsu; Tontonoz, Peter.
Afiliação
  • Choi J; Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA. Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Gao J; Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA. Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Kim J; Department of Neuroscience, Mayo Graduate School, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA.
  • Hong C; Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA. Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Kim J; Department of Neuroscience, Mayo Graduate School, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA. ptontonoz@mednet.ucla.edu kim.jungsu@mayo.edu.
  • Tontonoz P; Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA. Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. ptontonoz@mednet.ucla.edu kim.jungsu@mayo.edu.
Sci Transl Med ; 7(314): 314ra184, 2015 Nov 18.
Article em En | MEDLINE | ID: mdl-26582899
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Apolipoproteínas E / Encéfalo / Receptores de LDL / Peptídeos beta-Amiloides / Ubiquitina-Proteína Ligases / Doença de Alzheimer / Amiloidose Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Apolipoproteínas E / Encéfalo / Receptores de LDL / Peptídeos beta-Amiloides / Ubiquitina-Proteína Ligases / Doença de Alzheimer / Amiloidose Idioma: En Ano de publicação: 2015 Tipo de documento: Article