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Relationship between body mass index and hippocampal glutamate/glutamine in bipolar disorder.
Bond, David J; da Silveira, Leonardo Evangelista; MacMillan, Erin L; Torres, Ivan J; Lang, Donna J; Su, Wayne; Honer, William G; Lam, Raymond W; Yatham, Lakshmi N.
Afiliação
  • Bond DJ; David J. Bond, MD, PhD, Mood Disorders Centre, University of British Columbia, Vancouver, Canada and Department of Psychiatry, University of Minnesota, Minneapolis, USA; Leonardo Evangelista da Silveira, MD, Mood Disorders Centre, University of British Columbia, Vancouver, Canada, Laboratory of Mole
  • da Silveira LE; David J. Bond, MD, PhD, Mood Disorders Centre, University of British Columbia, Vancouver, Canada and Department of Psychiatry, University of Minnesota, Minneapolis, USA; Leonardo Evangelista da Silveira, MD, Mood Disorders Centre, University of British Columbia, Vancouver, Canada, Laboratory of Mole
  • MacMillan EL; David J. Bond, MD, PhD, Mood Disorders Centre, University of British Columbia, Vancouver, Canada and Department of Psychiatry, University of Minnesota, Minneapolis, USA; Leonardo Evangelista da Silveira, MD, Mood Disorders Centre, University of British Columbia, Vancouver, Canada, Laboratory of Mole
  • Torres IJ; David J. Bond, MD, PhD, Mood Disorders Centre, University of British Columbia, Vancouver, Canada and Department of Psychiatry, University of Minnesota, Minneapolis, USA; Leonardo Evangelista da Silveira, MD, Mood Disorders Centre, University of British Columbia, Vancouver, Canada, Laboratory of Mole
  • Lang DJ; David J. Bond, MD, PhD, Mood Disorders Centre, University of British Columbia, Vancouver, Canada and Department of Psychiatry, University of Minnesota, Minneapolis, USA; Leonardo Evangelista da Silveira, MD, Mood Disorders Centre, University of British Columbia, Vancouver, Canada, Laboratory of Mole
  • Su W; David J. Bond, MD, PhD, Mood Disorders Centre, University of British Columbia, Vancouver, Canada and Department of Psychiatry, University of Minnesota, Minneapolis, USA; Leonardo Evangelista da Silveira, MD, Mood Disorders Centre, University of British Columbia, Vancouver, Canada, Laboratory of Mole
  • Honer WG; David J. Bond, MD, PhD, Mood Disorders Centre, University of British Columbia, Vancouver, Canada and Department of Psychiatry, University of Minnesota, Minneapolis, USA; Leonardo Evangelista da Silveira, MD, Mood Disorders Centre, University of British Columbia, Vancouver, Canada, Laboratory of Mole
  • Lam RW; David J. Bond, MD, PhD, Mood Disorders Centre, University of British Columbia, Vancouver, Canada and Department of Psychiatry, University of Minnesota, Minneapolis, USA; Leonardo Evangelista da Silveira, MD, Mood Disorders Centre, University of British Columbia, Vancouver, Canada, Laboratory of Mole
  • Yatham LN; David J. Bond, MD, PhD, Mood Disorders Centre, University of British Columbia, Vancouver, Canada and Department of Psychiatry, University of Minnesota, Minneapolis, USA; Leonardo Evangelista da Silveira, MD, Mood Disorders Centre, University of British Columbia, Vancouver, Canada, Laboratory of Mole
Br J Psychiatry ; 208(2): 146-52, 2016 Feb.
Article em En | MEDLINE | ID: mdl-26585092
ABSTRACT

BACKGROUND:

We previously reported that patients with early-stage bipolar disorder, but not healthy comparison controls, had body mass index (BMI)-related volume reductions in limbic brain areas, suggesting that the structural brain changes characteristic of bipolar disorder were more pronounced with increased weight.

AIMS:

To determine whether the most consistently reported neurochemical abnormality in bipolar disorder, increased glutamate/glutamine (Glx), was also more prominent with higher BMI.

METHOD:

We used single-voxel proton magnetic resonance spectroscopy to measure hippocampal Glx in 51 patients with first-episode mania (mean BMI = 24.1) and 28 healthy controls (mean BMI = 23.3).

RESULTS:

In patients, but not healthy controls, linear regression demonstrated that higher BMI predicted greater Glx. Factorial ANCOVA showed a significant BMI × diagnosis interaction, confirming a distinct effect of weight on Glx in patients.

CONCLUSIONS:

Together with our volumetric studies, these results suggest that higher BMI is associated with more pronounced structural and neurochemical limbic brain changes in bipolar disorder, even in early-stage patients with low obesity rates.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtorno Bipolar / Índice de Massa Corporal / Ácido Glutâmico / Glutamina / Hipocampo Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtorno Bipolar / Índice de Massa Corporal / Ácido Glutâmico / Glutamina / Hipocampo Idioma: En Ano de publicação: 2016 Tipo de documento: Article