DNA methylation and hydroxymethylation in hematologic differentiation and transformation.
Curr Opin Cell Biol
; 37: 91-101, 2015 Dec.
Article
em En
| MEDLINE
| ID: mdl-26595486
ABSTRACT
Maintenance of the balance of DNA methylation and demethylation is fundamental for normal cellular development and function. Members of the Ten-Eleven-Translocation (TET) family proteins are Fe(II)-dependent and 2-oxoglutarate-dependent dioxygenases that catalyze sequential oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and subsequent oxidized derivatives in DNA. In addition to their roles as intermediates in DNA demethylation, these oxidized methylcytosines are novel epigenetic modifications of DNA. DNA methylation and hydroxymethylation profiles are markedly disrupted in a wide range of cancers but how these changes are related to the pathogenesis of cancers is still ambiguous. In this review, we discuss the current understanding of TET protein functions in normal and malignant hematopoietic development and the ongoing questions to be resolved.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Células Sanguíneas
/
Diferenciação Celular
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Metilação de DNA
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article