Strategies for functional bioscaffold-based skeletal muscle reconstruction.
Ann Transl Med
; 3(17): 256, 2015 Oct.
Article
em En
| MEDLINE
| ID: mdl-26605302
ABSTRACT
Tissue engineering and regenerative medicine-based strategies for the reconstruction of functional skeletal muscle tissue have included cellular and acellular approaches. The use of acellular biologic scaffold material as a treatment for volumetric muscle loss (VML) in five patients has recently been reported with a generally favorable outcome. Further studies are necessary for a better understanding of the mechanism(s) behind acellular bioscaffold-mediated skeletal muscle repair, and for combination cell-based/bioscaffold based approaches. The present overview highlights the current thinking on bioscaffold-based remodeling including the associated mechanisms and the future of scaffold-based skeletal muscle reconstruction.
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MEDLINE
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2015
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Article