DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of Cancer.
Biomolecules
; 5(4): 3204-59, 2015 Nov 20.
Article
em En
| MEDLINE
| ID: mdl-26610585
ABSTRACT
For decades, radiotherapy and chemotherapy were the two only approaches exploiting DNA repair processes to fight against cancer. Nowadays, cancer therapeutics can be a major challenge when it comes to seeking personalized targeted medicine that is both effective and selective to the malignancy. Over the last decade, the discovery of new targeted therapies against DNA damage signalling and repair has offered the possibility of therapeutic improvements in oncology. In this review, we summarize the current knowledge of DNA damage signalling and repair inhibitors, their molecular and cellular effects, and future therapeutic use.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Dano ao DNA
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Enzimas Reparadoras do DNA
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Inibidores Enzimáticos
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Neoplasias
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Antineoplásicos
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article