BDNF/TrkB Signaling as a Potential Novel Target in Pediatric Brain Tumors: Anticancer Activity of Selective TrkB Inhibition in Medulloblastoma Cells.

Thomaz, Amanda; Jaeger, Mariane; Buendia, Marienela; Bambini-Junior, Victorio; Gregianin, Lauro José; Brunetto, Algemir Lunardi; Brunetto, André T; de Farias, Caroline Brunetto; Roesler, Rafael

Thomaz, Amanda; Jaeger, Mariane; Buendia, Marienela; Bambini-Junior, Victorio; Gregianin, Lauro José; Brunetto, Algemir Lunardi; Brunetto, André T; de Farias, Caroline Brunetto; Roesler, Rafael.

Afiliação

Thomaz A; Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, 90035-003, Porto Alegre, RS, Brazil.
Jaeger M; Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, Rua Sarmento Leite, 500 (ICBS, Campus Centro/UFRGS), 90050-170, Porto Alegre, RS, Brazil.
Buendia M; Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, 90035-003, Porto Alegre, RS, Brazil.
Bambini-Junior V; Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, Rua Sarmento Leite, 500 (ICBS, Campus Centro/UFRGS), 90050-170, Porto Alegre, RS, Brazil.
Gregianin LJ; Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, 90035-003, Porto Alegre, RS, Brazil.
Brunetto AL; Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, Rua Sarmento Leite, 500 (ICBS, Campus Centro/UFRGS), 90050-170, Porto Alegre, RS, Brazil.
Brunetto AT; Laboratory of Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, 21040-360, Rio de Janeiro, RJ, Brazil.
de Farias CB; Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, 90035-003, Porto Alegre, RS, Brazil.
Roesler R; Department of Pediatrics, Faculty of Medicine, Federal University of Rio Grande do Sul, 90035-003, Porto Alegre, RS, Brazil.

J Mol Neurosci ; 59(3): 326-33, 2016 Jul.

Article em En | MEDLINE | ID: mdl-26614346

Assuntos

Antineoplásicos/farmacologia; Azepinas/farmacologia; Benzamidas/farmacologia; Neoplasias Encefálicas/metabolismo; Meduloblastoma/metabolismo; Glicoproteínas de Membrana/metabolismo; Inibidores de Proteínas Quinases/farmacologia; Proteínas Tirosina Quinases/metabolismo; Fator Neurotrófico Derivado do Encéfalo/farmacologia; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Humanos; Glicoproteínas de Membrana/antagonistas & inibidores; Glicoproteínas de Membrana/genética; Proteínas Tirosina Quinases/antagonistas & inibidores; Proteínas Tirosina Quinases/genética; Receptor trkB; Transdução de Sinais

Palavras-chave

Brain tumor; Brain-derived neurotrophic factor; Childhood cancer; Medulloblastoma; TrkB

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Azepinas / Benzamidas / Neoplasias Encefálicas / Proteínas Tirosina Quinases / Glicoproteínas de Membrana / Inibidores de Proteínas Quinases / Meduloblastoma / Antineoplásicos Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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