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Site-Specific Polymer Conjugation Stabilizes Therapeutic Enzymes in the Gastrointestinal Tract.
Schulz, Jessica D; Patt, Melanie; Basler, Sophie; Kries, Hajo; Hilvert, Donald; Gauthier, Marc A; Leroux, Jean-Christophe.
Afiliação
  • Schulz JD; Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology Zurich (ETH Zurich), 8093, Zurich, Switzerland.
  • Patt M; Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology Zurich (ETH Zurich), 8093, Zurich, Switzerland.
  • Basler S; Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology Zurich (ETH Zurich), 8093, Zurich, Switzerland.
  • Kries H; Department of Chemistry and Applied Biosciences, Laboratory of Organic Chemistry, Swiss Federal Institute of Technology Zurich (ETH Zurich), 8093, Zurich, Switzerland.
  • Hilvert D; Department of Chemistry and Applied Biosciences, Laboratory of Organic Chemistry, Swiss Federal Institute of Technology Zurich (ETH Zurich), 8093, Zurich, Switzerland.
  • Gauthier MA; EMT Research Center, Institut National de la Recherche Scientifique (INRS), J3X 1S2 Varennes, Quebec, Canada.
  • Leroux JC; Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology Zurich (ETH Zurich), 8093, Zurich, Switzerland.
Adv Mater ; 28(7): 1455-60, 2016 Feb 17.
Article em En | MEDLINE | ID: mdl-26640034
The site-specific conjugation of polymers to multiple engineered cysteine residues of a prolyl endopeptidase leads to its stabilization in the gastrointestinal tract of rats, without compromising the activity relative to the native enzyme. The importance of polymer attachment sites is investigated, as well as the significance of polymer structure.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Endopeptidases / Polietilenoglicóis / Trato Gastrointestinal Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Endopeptidases / Polietilenoglicóis / Trato Gastrointestinal Idioma: En Ano de publicação: 2016 Tipo de documento: Article