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Pharmacokinetics and pharmacodynamics of mycophenolic acid in Nagase analbuminemic rats: Evaluation of protein binding effects using the modeling and simulation approach.
Yoshimura, Kazuaki; Yano, Ikuko; Kawanishi, Misaki; Nakagawa, Shunsaku; Yonezawa, Atsushi; Matsubara, Kazuo.
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  • Yoshimura K; Department of Clinical Pharmacy and Education, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan; Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Sakyo-ku, Kyoto 606-8507, Japan. Electronic address: yoshimura.kazuaki.52r@st
  • Yano I; Department of Clinical Pharmacy and Education, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan; Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Sakyo-ku, Kyoto 606-8507, Japan. Electronic address: iyano@kuhp.kyoto-u.ac.jp
  • Kawanishi M; Department of Clinical Pharmacy and Education, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan; Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Sakyo-ku, Kyoto 606-8507, Japan. Electronic address: misaki.kawanishi@shionog
  • Nakagawa S; Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Sakyo-ku, Kyoto 606-8507, Japan. Electronic address: nakashun@kuhp.kyoto-u.ac.jp.
  • Yonezawa A; Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Sakyo-ku, Kyoto 606-8507, Japan. Electronic address: ayone@kuhp.kyoto-u.ac.jp.
  • Matsubara K; Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Sakyo-ku, Kyoto 606-8507, Japan. Electronic address: kmatsuba@kuhp.kyoto-u.ac.jp.
Drug Metab Pharmacokinet ; 30(6): 441-8, 2015 Dec.
Article em En | MEDLINE | ID: mdl-26643991
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Simulação por Computador / Hipoalbuminemia / Imunossupressores / Modelos Biológicos / Ácido Micofenólico Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Simulação por Computador / Hipoalbuminemia / Imunossupressores / Modelos Biológicos / Ácido Micofenólico Idioma: En Ano de publicação: 2015 Tipo de documento: Article