Taichunamides: Prenylated Indole Alkaloids from Aspergillus taichungensis (IBT 19404).
Angew Chem Int Ed Engl
; 55(3): 1128-32, 2016 Jan 18.
Article
em En
| MEDLINE
| ID: mdl-26644336
ABSTRACT
Seven new prenylated indole alkaloids, taichunamidesâ
A-G, were isolated from the fungus Aspergillus taichungensis (IBT 19404). Taichunamidesâ
A and B contained an azetidine and 4-pyridone units, respectively, and are likely biosynthesized from notoamideâ
S via (+)-6-epi-stephacidinâ
A. Taichunamidesâ
C and D contain endoperoxide and methylsulfonyl units, respectively. This fungus produced indole alkaloids containing an anti-bicyclo[2.2.2]diazaoctane core, whereas A. protuberus and A. amoenus produced congeners with a syn-bicyclo[2.2.2]diazaoctane core. Plausible biosynthetic pathways to access these cores within the three species likely arise from an intramolecular hetero Diels-Alder reaction.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Aspergillus
/
Alcaloides Indólicos
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article