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Facile synthesis of aza-spirocyclopropanyl oxindoles by the reaction of 3-(2-bromoethyl)-indole with 2,3-dimethylimidazole-1-sulfonyl azide triflate.
Shen, Mei-Hua; Xu, Ke; Sun, Chu-Han; Xu, Hua-Dong.
Afiliação
  • Shen MH; School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou, Jiangsu Province 213164, China. shenmh@cczu.edu.cn hdxu@cczu.edu.cn.
Org Biomol Chem ; 14(4): 1272-6, 2016 Jan 28.
Article em En | MEDLINE | ID: mdl-26645361
3-(2-Bromoethyl)indole reacts with 2,3-dimethylimidazole-1-sulfonyl azide triflate to give an intermediate N-(2,3-dimethylimidazole)-1-sulfonyl aza-spirocyclopropanyloxindole. This reactive species is captured by an alcohol or amine to afford the corresponding aza-spirooxindole sulfonate and sulfonamide.

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2016 Tipo de documento: Article