Interferon γ (IFNγ) Signaling via Mechanistic Target of Rapamycin Complex 2 (mTORC2) and Regulatory Effects in the Generation of Type II Interferon Biological Responses.
J Biol Chem
; 291(5): 2389-96, 2016 Jan 29.
Article
em En
| MEDLINE
| ID: mdl-26645692
ABSTRACT
We provide evidence for a unique pathway engaged by the type II IFN receptor, involving mTORC2/AKT-mediated downstream regulation of mTORC1 and effectors. These events are required for formation of the eukaryotic translation initiation factor 4F complex (eIF4F) and initiation of mRNA translation of type II interferon-stimulated genes. Our studies establish that Rictor is essential for the generation of type II IFN-dependent antiviral and antiproliferative responses and that it controls the generation of type II IFN-suppressive effects on normal and malignant hematopoiesis. Together, our findings establish a central role for mTORC2 in IFNγ signaling and type II IFN responses.
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Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
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Proteínas de Transporte
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Interferon gama
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Receptores de Interferon
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Fator de Iniciação 4F em Eucariotos
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Complexos Multiproteicos
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Serina-Treonina Quinases TOR
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article