Human colon cancer targeted pro-apoptotic, anti-metastatic and cytostatic effects of binuclear Silver(I)-N-Heterocyclic carbene (NHC) complexes.

Asif, Muhammad; Iqbal, Muhammad Adnan; Hussein, Mouayed A; Oon, Chern Ein; Haque, Rosenani A; Khadeer Ahamed, Mohamed B; Abdul Majid, Aman Shah; Abdul Majid, Amin Malik Shah

Asif, Muhammad; Iqbal, Muhammad Adnan; Hussein, Mouayed A; Oon, Chern Ein; Haque, Rosenani A; Khadeer Ahamed, Mohamed B; Abdul Majid, Aman Shah; Abdul Majid, Amin Malik Shah.

Afiliação

Asif M; EMAN Testing and Research Laboratory, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800-USM, Penang, Malaysia.
Iqbal MA; School of Chemical Sciences, Universiti Sains Malaysia, 11800-USM, Penang, Malaysia; Department of Chemistry, University of Agriculture, Faisalabad 38000, Pakistan; Community College, University of Agriculture, Faisalabad 38000, Pakistan.
Hussein MA; University of Basrah, College of Science, Department of Chemistry, Basra 61004, Iraq.
Oon CE; Institute for Research in Molecular Medicine, Universiti Sains Malaysia, 11800-USM, Penang, Malaysia.
Haque RA; School of Chemical Sciences, Universiti Sains Malaysia, 11800-USM, Penang, Malaysia. Electronic address: rosenani@usm.my.
Khadeer Ahamed MB; EMAN Testing and Research Laboratory, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800-USM, Penang, Malaysia.
Abdul Majid AS; Advanced Medical and Dental Institute, Universiti Sains Malaysia, Penang, 13200, Malaysia.
Abdul Majid AMS; EMAN Testing and Research Laboratory, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800-USM, Penang, Malaysia. Electronic address: aminmalikshah@usm.my.

Eur J Med Chem ; 108: 177-187, 2016 Jan 27.

Article em En | MEDLINE | ID: mdl-26649905

Assuntos

Antineoplásicos/farmacologia; Apoptose/efeitos dos fármacos; Neoplasias do Colo/tratamento farmacológico; Complexos de Coordenação/farmacologia; Compostos Heterocíclicos/farmacologia; Antineoplásicos/síntese química; Antineoplásicos/química; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Neoplasias do Colo/patologia; Complexos de Coordenação/síntese química; Complexos de Coordenação/química; Relação Dose-Resposta a Droga; Ensaios de Seleção de Medicamentos Antitumorais; Compostos Heterocíclicos/síntese química; Compostos Heterocíclicos/química; Humanos; Estrutura Molecular; Relação Estrutura-Atividade

Palavras-chave

Ag(I)NHC; Antimetastatic; Apoptosis; HCT 116; Spheroid assay

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Apoptose / Neoplasias do Colo / Complexos de Coordenação / Compostos Heterocíclicos / Antineoplásicos Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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