Oncogenic MicroRNAs Characterization in Clear Cell Renal Cell Carcinoma.
Int J Mol Sci
; 16(12): 29219-25, 2015 Dec 08.
Article
em En
| MEDLINE
| ID: mdl-26670229
ABSTRACT
A key challenge for the improvement of clear cell renal cell carcinoma (ccRCC) management could derive from a deeper characterization of the biology of these neoplasms that could greatly improve the diagnosis, prognosis and treatment choice. The aim of this study was to identify specific miRNAs that are deregulated in tumor vs. normal kidney tissues and that could impact on the biology of ccRCC. To this end we selected four miRNAs (miR-21-5p, miR-210-3p, miR-185-5p and miR-221-3p) and their expression has been evaluated in a retrospective cohort of formalin-fixed paraffin-embedded (FFPE) tissues from 20 ccRCC patients who underwent surgical nephrectomy resection. miR-21-5p and miR-210-3p resulted the most significantly up-regulated miRNAs in this patient cohort, highlighting these onco-miRNAs as possible relevant players involved in ccRCC tumorigenesis. Thus, this study reports the identification of specific oncogenic miRNAs that are altered in ccRCC tissues and suggests that they might be useful biomarkers in ccRCC management.
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MEDLINE
Assunto principal:
Carcinoma de Células Renais
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Transformação Celular Neoplásica
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MicroRNAs
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Neoplasias Renais
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article